4-(1,3-Thiazol-2-yl)benzaldehyde → (4-(Thiazol-4-yl)phenyl)methanol

반응식

[S:1]1[CH:5]=[C:4]([C:6]2[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][CH:7]=2)[N:3]=[CH:2]1.S1C=CN=C1C1C=CC(C=O)=CC=1>>[S:1]1[CH:5]=[C:4]([C:6]2[CH:7]=[CH:8][C:9]([CH2:10][OH:11])=[CH:12][CH:13]=2)[N:3]=[CH:2]1

참가 물질

반응물 2

HCID 105356554-(1,3-Thiazol-2-yl)benzaldehyde

HCID 150453304-(Thiazol-4-yl)benzaldehyde

생성물 1

HCID 66717421(4-(Thiazol-4-yl)phenyl)methanol수율 83%

실험 절차

Reaction and post-treatment were carried out in the same manner as in Reference Example 4-(a) except for using 4-(thiazol-4-yl)benzaldehyde (1.28 g, 6:76 mmol) obtained in Reference Example 15-(a) in place of 4-(thiazol-2-yl)benzaldehyde to afford the title compound (1.07 g) as a white solid. (Yield: 83%)

후처리

customReaction

출처 및 근거

ORD 기록: ord-d8a81e7707e54f2da421b7b22420bc0c
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08685986B2

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