Acetyl chloride → N-[(6-Bromopyridin-2-yl)sulphonyl]acetamide

HRID 2359918노트

반응식

HRID 2359918 반응식
[Br:1][C:2]1[N:7]=[C:6]([S:8]([NH2:11])(=[O:10])=[O:9])[CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:18](Cl)(=[O:20])[CH3:19]>C(#N)C>[Br:1][C:2]1[N:7]=[C:6]([S:8]([NH:11][C:18](=[O:20])[CH3:19])(=[O:9])=[O:10])[CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 11430Potassium CarbonateHCID 573458166-Bromopyridine-2-sulfonamide

생성물 1

HCID 86667250N-[(6-Bromopyridin-2-yl)sulphonyl]acetamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

6-Bromopyridine-2-sulphonamide (0.5 g, 2.11 mmol, prepared by the methods described in WO2005/058299) and potassium carbonate (2.92 g, 21.1 mmol) were initially charged in acetonitrile (10 ml). While cooling with ice, acetyl chloride (1.16 g, 14.8 mmol) was added dropwise and the reaction mixture was stirred at room temperature for 16 h. The solvent was removed under reduced pressure, and the residue was taken up in water and acidified with dilute hydrochloric acid solution. It was extracted with ethyl acetate and the solvent was removed under reduced pressure. This gave 0.54 g (85% of theory) of N-[(6-bromopyridin-2-yl)sulphonyl]-acetamide.

후처리

  1. additionwas added dropwise
  2. customThe solvent was removed under reduced pressure
  3. extractionIt was extracted with ethyl acetate
  4. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-e4177b39fa5f40ca9af2143ba7806818
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08686004B2

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