Hydrogen chloride-ethyl acetate → (Cyclohexylmethyl)(methyl)amine hydrochloride
반응식
[CH:1]1([CH2:7][N:8](C)[C:9](=O)OC(C)(C)C)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:17].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:17].[CH:1]1([CH2:7][NH:8][CH3:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1참가 물질
4
실험 절차
To a solution of tert-butyl N-(cyclohexylmethyl)-N-methylcarbamate (370 mg, 1.6 mmol) in 4.0 mL of ethyl acetate was added 4 M HCl-ethyl acetate (4 mL). After being stirred at room temperature for 1.5 h, the reaction mixture was concentrated in vacuo, and the residue was rinsed with hexane to obtain the title compound (266 mg, 100%).
후처리
- concentrationthe reaction mixture was concentrated in vacuo
- washthe residue was rinsed with hexane
출처 및 근거
- ORD 기록
- ord-93b77bf83ce045ec8da2cbc16bcb0bb2
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08686024B2
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