Hydrogen chloride-ethyl acetate → Methyl((oxan-4-yl)methyl)amine hydrochloride
반응식
[CH3:1][N:2]([CH2:10][CH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)C(=O)OC(C)(C)C.[ClH:17].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:17].[CH3:1][NH:2][CH2:10][CH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1참가 물질
4
실험 절차
To a solution of tert-butyl N-methyl-N-(4-tetrahydropyranylmethyl)carbamate (600 mg, 2.6 mmol) in 4.0 mL of ethyl acetate was added 4 M HCl-ethyl acetate (4 mL). After being stirred at room temperature for 1.5 h, the reaction mixture was concentrated in vacuo, and the residue was rinsed with hexane to obtain the title compound (356 mg, 82%).
후처리
- concentrationthe reaction mixture was concentrated in vacuo
- washthe residue was rinsed with hexane
출처 및 근거
- ORD 기록
- ord-47a6b258785245cd8d5f4810cc91d96f
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08686024B2
반응 노트
불러오는 중…