3-Ethoxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride) → 3-Chloro-3'-ethoxy-2',5-difluorobiphenyl-4-amine

반응식

Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([Cl:10])[CH:3]=1.[CH2:11]([O:13][C:14]1[C:15]([F:23])=[C:16](B(O)O)[CH:17]=[CH:18][CH:19]=1)[CH3:12]>>[Cl:10][C:4]1[CH:3]=[C:2]([C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([O:13][CH2:11][CH3:12])[C:15]=2[F:23])[CH:8]=[C:7]([F:9])[C:5]=1[NH2:6]

참가 물질

반응물 2

HCID 162177593-Ethoxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)

HCID 204346204-Bromo-2-chloro-6-fluoroaniline

생성물 1

HCID 669978053-Chloro-3'-ethoxy-2',5-difluorobiphenyl-4-amine수율 43.2%

실험 절차

The title compound (65 mg) was prepared from 4-bromo-2-chloro-6-fluoroaniline (120 mg, 0.53 mmol) and 3-ethoxy-2-fluorophenylboronic acid (120 mg, 0.69 mmol) as a colourless liquid.

출처 및 근거

ORD 기록: ord-cc3d2de445f94b82bf046c813a399eab
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08686048B2

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