4-Bromo-2,6-difluoroaniline → 3'-(Ethylthio)-3,5-difluorobiphenyl-4-amine

HRID 2360452

반응식

HRID 2360452 반응식
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[CH2:11]([S:13][C:14]1[CH:15]=[C:16](B(O)O)[CH:17]=[CH:18][CH:19]=1)[CH3:12]>>[CH2:11]([S:13][C:14]1[CH:19]=[C:18]([C:2]2[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=2)[CH:17]=[CH:16][CH:15]=1)[CH3:12]

참가 물질

3

반응물 2

HCID 6101914-Bromo-2,6-difluoroanilineHCID 3484915[3-(Ethylthio)phenyl]boronic acid

생성물 1

HCID 669968323'-(Ethylthio)-3,5-difluorobiphenyl-4-amine수율 70.7%

실험 절차

The title compound (900 mg) was prepared from 4-bromo-2,6-difluoroaniline (1 g, 4.8 mmol) and 3-(ethylthio)phenylboronic acid (1.13 g, 6.24 mmol) as a colourless liquid.

출처 및 근거

ORD 기록
ord-0ace4475fbde40139f1acea75af03bb1
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08686048B2

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