4-Bromo-2,6-difluoroaniline → HCID 66997723, 화합물

반응식

Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[CH:11]1([O:14][C:15]2[CH:16]=[C:17](B3OC(C)(C)C(C)(C)O3)[CH:18]=[CH:19][CH:20]=2)[CH2:13][CH2:12]1>>[CH:11]1([O:14][C:15]2[CH:20]=[C:19]([C:2]3[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=3)[CH:18]=[CH:17][CH:16]=2)[CH2:13][CH2:12]1

참가 물질

반응물 2

HCID 6101914-Bromo-2,6-difluoroaniline

HCID 574676352-[3-(Cyclopropyloxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

생성물 1

HCID 66997723HCID 66997723, 화합물수율 11.3%

실험 절차

The title compound (170 mg) was prepared from 4-bromo-2,6-difluoroaniline (1.2 g, 5.76 mmol) and 2-(3-cyclopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.5 g, 5.76 mmol) as a yellow liquid.

출처 및 근거

ORD 기록: ord-c975c85140864a0e9a9aa3ee6f4f5e51
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08686048B2

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