4-Bromo-3-fluoroaniline → 3'-(Ethylthio)-2-fluorobiphenyl-4-amine

HRID 2360458

반응식

HRID 2360458 반응식
Br[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[F:9].[CH2:10]([S:12][C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][CH:18]=1)[CH3:11]>>[CH2:10]([S:12][C:13]1[CH:18]=[C:17]([C:2]2[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=2[F:9])[CH:16]=[CH:15][CH:14]=1)[CH3:11]

참가 물질

3

반응물 2

HCID 8218484-Bromo-3-fluoroanilineHCID 3484915[3-(Ethylthio)phenyl]boronic acid

생성물 1

HCID 669976243'-(Ethylthio)-2-fluorobiphenyl-4-amine수율 108.7%

실험 절차

The title compound (430 mg) was prepared from 4-bromo-3-fluoroaniline (300 mg, 1.6 mmol) and 3-(ethylthio)phenylboronic acid (370 mg, 2.0 mmol) as a yellow liquid.

출처 및 근거

ORD 기록
ord-95b66ac82b58474db103f4aeabc7cc43
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08686048B2

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