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Triethylamine → 5-Tert-butyl-2-methoxy-3-nitro-benzyl methanesulphonate

HRID 2360514
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HRID 2360514 반응식
[C:1]([C:5]1[CH:6]=[C:7]([N+:15]([O-:17])=[O:16])[C:8]([O:13][CH3:14])=[C:9]([CH2:11][OH:12])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>ClCCl>[CH3:25][S:26]([O:12][CH2:11][C:9]1[CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=[C:7]([N+:15]([O-:17])=[O:16])[C:8]=1[O:13][CH3:14])(=[O:28])=[O:27]
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참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 58493934(5-Tert-butyl-2-methoxy-3-nitrophenyl)methanol

생성물 1

HCID 584939545-Tert-butyl-2-methoxy-3-nitro-benzyl methanesulphonate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

3.43 g (5-tert-butyl-2-methoxy-3-nitro-phenyl)-methanol are dissolved in 30 ml dichloromethane, combined with 2.39 ml of triethylamine and cooled to 0° C. 1.2 g of methanesulphonic acid chloride are added dropwise and the mixture is stirred for 2 hours. Then it is diluted with dichloromethane and washed 3 times with water and once with saturated aqueous sodium chloride solution. After drying with magnesium sulphate the solvents are eliminated in vacuo and the product thus obtained is further reacted directly.

후처리

  1. washwashed 3 times with water
  2. dry with materialAfter drying with magnesium sulphate the solvents
  3. customthe product thus obtained
  4. customis further reacted directly

출처 및 근거

ORD 기록
ord-e99786ebe4314e7fb79c507b25c96553
출처 데이터셋
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08686022B2

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