methyl (2R)-2-aminopentanoate hydrochloride → HCID 86680333, 화합물

반응식

Cl.[CH3:2]OC(=O)[C@H](N)CCC.[CH2:11]([C@@H:13]1[CH2:18][NH:17][C@@H:16]([CH3:19])[CH2:15][N:14]1[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1)[CH3:12]>>[CH3:28][O:27][C:24]1[CH:23]=[CH:22][C:21]([CH2:20][N:14]2[CH2:15][C@H:16]([CH3:19])[NH:17][CH2:18][C@H:13]2[CH2:11][CH2:12][CH3:2])=[CH:26][CH:25]=1

참가 물질

반응물 2

HCID 78358361methyl (2R)-2-aminopentanoate hydrochloride

HCID 86680329HCID 86680329, 화합물

생성물 1

HCID 86680333HCID 86680333, 화합물

실험 절차

(2R,5S)-1-(4-Methoxy-benzyl)-5-methyl-2-propyl-piperazine was prepared from (R)-2-amino-pentanoic acid methyl ester hydrochloride in analogy to the synthesis of (2R,5S)-2-ethyl-1-(4-methoxy-benzyl)-5-methyl-piperazine.

출처 및 근거

ORD 기록: ord-5cad7048688e44129f720a609e891234
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08686150B2

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