Benzyl Bromide → 1-benzyl-4-methyl-9H-indeno[2,1-b]pyridinium bromide

HRID 2360790노트

반응식

HRID 2360790 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[C:3]=12.[CH2:15]([Br:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CC(C)=O>[Br-:22].[CH2:15]([N+:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH2:8][C:4]=12)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

4

반응물 2

HCID 7498Benzyl BromideHCID 125062784-methyl-9H-indeno[2,1-b]pyridine

생성물 1

HCID 671942071-benzyl-4-methyl-9H-indeno[2,1-b]pyridinium bromide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 4-methyl-9H-indeno[2,1-b]pyridine (0.64 g) and benzyl bromide (0.42 mL) in acetone (5 mL) is stirred at reflux temperature for 4 h. After cooling to room temperature, the precipitate is separated by filtration, washed with little diethyl ether, and dried to give the title compound as a beige solid. Yield: 0.93 g (75% of theory); LC (method 1): tR=2.49 min; Mass spectrum (ESI+): m/z=272 [M−Br]+.

후처리

  1. temperatureat reflux temperature for 4 h
  2. customthe precipitate is separated by filtration
  3. washwashed with little diethyl ether
  4. customdried

출처 및 근거

ORD 기록
ord-db8fd6958a7b42c98eb2d4cea8c7484c
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08686149B2

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