Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methyl-3-phenyl-1-propanol → Benzenepropanol, 4-(1,1-dimethylethyl)-beta-methyl-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methyl-3-phenyl-1-propanol | HCID 95640 | — |
| 촉매 | Ferrous Chloride | HCID 24458 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 용매 | Cyclohexane | HCID 8078 | — |
| 생성물 | Benzenepropanol, 4-(1,1-dimethylethyl)-beta-methyl- | HCID 92013 | 84% |
반응 단계
DE 29 52 719 likewise describes the iron chloride-catalyzed Friedel-Crafts alkylation of 2-methyl-3-phenylpropanol. In cyclohexane or dichloroethane as solvent, a yield of 84-86% of 2-methyl-3-(4-tert-butylphenyl)propanol was obtained. The formation of the m-isomeric compound (2-methyl-3-(3-tert-butylphenyl)propanol), was not demonstrated. A disadvantage of the described Friedel-Crafts alkylations is the small amount of the m-isomeric compound formed (m:p ratio is max. 1:5).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08686193B2 |
| 출처 데이터셋 | uspto-grants-2014_04 |
| ORD ID | ord-46c9d158b7d14f4eb5e4b74b90ffabd0 |
| 출처 메모 | uspto-grants-2014_04 |