Ammonia → 6-Hydroxyquinoline-5-carboxamide

반응식

C[O:2][C:3]([C:5]1[C:6]2[CH:7]=[CH:8][CH:9]=[N:10][C:11]=2[CH:12]=[CH:13][C:14]=1[OH:15])=O.[NH3:16]>>[OH:15][C:14]1[CH:13]=[CH:12][C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]=1[C:3]([NH2:16])=[O:2]

참가 물질

반응물 2

HCID 222Ammonia2회

HCID 19077292Methyl 6-hydroxyquinoline-5-carboxylate

생성물 1

HCID 212714806-Hydroxyquinoline-5-carboxamide

실험 절차

6-Hydroxy-5-quinolinecarboxylic acid methyl ester is reacted with excess ammonia in a steel bomb for 12-18 hr. The excess ammonia is allowed to evaporate and the residue is crystallized from a suitable solvent to give the title compound.

후처리

customto evaporate
customthe residue is crystallized from a suitable solvent

출처 및 근거

ORD 기록: ord-1cfc77f70f1048b2b217c101bb059010
출처 데이터셋: uspto-grants-1987_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04642343

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