7-Bromoquinoline → N-Methyl-4-(quinolin-7-yl)aniline

HRID 2361476

반응식

HRID 2361476 반응식
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:12][NH:13][C:14]1[CH:19]=[CH:18][C:17](B2OC(C)(C)C(C)(C)O2)=[CH:16][CH:15]=1>>[CH3:12][NH:13][C:14]1[CH:19]=[CH:18][C:17]([C:2]2[CH:11]=[C:10]3[C:5]([CH:6]=[CH:7][CH:8]=[N:9]3)=[CH:4][CH:3]=2)=[CH:16][CH:15]=1

참가 물질

3

반응물 2

HCID 5212597-BromoquinolineHCID 11957892N-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

생성물 1

HCID 58362705N-Methyl-4-(quinolin-7-yl)aniline

실험 절차

N-Methyl-4-(quinolin-7-yl)aniline T515 was prepared using general procedure A from 7-bromoquinoline (41 mg, 0.2 mmol) and N-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (46 mg, 0.2 mmol). T515 was obtained as a yellow wax (18 mg, 38%). 1H NMR (400 MHz, CDCl3): δ 8.90 (dd, J=4.0, 1.2 Hz, 1H), 8.26 (m, 1H), 8.13 (m, 1H), 7.82-7.81 (m, 2H), 7.64 (m, 2H), 7.34 (dd, J=8.4, 4.4 Hz, 1H), 6.73 (m, 2H), 2.90 (s, 3H); MS (ESI): 235 (M+H+).

후처리

  1. customT515 was obtained as a yellow wax (18 mg, 38%)

출처 및 근거

ORD 기록
ord-669a0f02e08641ff8bc4fb13d9462a3f
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691187B2

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