2-Bromo-4-nitroquinoline → N,N-dimethyl-5-(4-nitroquinolin-2-yl)pyridin-2-amine

HRID 2361491

반응식

HRID 2361491 반응식
Br[C:2]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:15][N:16]([CH3:26])[C:17]1[N:22]=[CH:21][C:20](B(O)O)=[CH:19][CH:18]=1>>[CH3:15][N:16]([CH3:26])[C:17]1[CH:18]=[CH:19][C:20]([C:2]2[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[CH:21][N:22]=1

참가 물질

3

반응물 2

HCID 5812662-Bromo-4-nitroquinolineHCID 27632716-(Dimethylamino)pyridine-3-boronic acid

생성물 1

HCID 58362513N,N-dimethyl-5-(4-nitroquinolin-2-yl)pyridin-2-amine

실험 절차

N,N-Dimethyl-5-(4-nitroquinolin-2-yl)pyridin-2-amine T480P was prepared using general procedure A from 2-Bromo-4-nitroquinoline (50 mg, 0.2 mmol) and (6-(dimethylamino)pyridin-3-yl)boronic acid (34 mg, 0.2 mmol). The product was obtained as a yellow solid (40 mg, 68%). 1H NMR (400 MHz, CDCl3): δ 8.99 (d, J=2.4 Hz, 1H), 8.36-8.34 (m, 2H), 8.30 (s, 1H), 8.19 (m, 1H), 7.81 (m, 1H), 7.65 (m, 1H), 6.66 (d, J=9.0 Hz, 1H), 3.21 (s, 6H); MS (ESI): 295 (M+H+).

출처 및 근거

ORD 기록
ord-973335e3efa44358ba62097aa0224b53
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691187B2

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