2-Hydroxyethyl acrylate → Demannose

A 40 mol % mannose polymer was prepared as follows. Allyl α-D-mannopyranoside (1.77 g, 8.0 mmol), 2-hydroxyethylacrylate (1.36 g, 11.7 mmol), N-(3-aminopropyl)methacrylamide hydrochloride (89.6 mg, 0.5 mmol) and 2,2′-Azobis-[2-(2-imidazolin-2-yl)-propane]dihydrochloride (23.7 mg, 0.073 mmol) were added into a 50 ml round bottom flask, followed by addition of water (28.8 ml). The mixture was dissolved under magnetic stirring at room temperature. After purging with nitrogen for 5 min, the mixture was heated to 60° C. and polymerized at that temperature for 12 hours. Upon cooling a slightly yellow and viscous solution was obtained. This solution was dialysed (25 k MWCO regenerated cellulose) overnight against water, and freeze-dried to obtain a white fluffy polymer.

1. dissolutionThe mixture was dissolved
2. customAfter purging with nitrogen for 5 min
3. temperaturethe mixture was heated to 60° C.
4. custompolymerized at that temperature for 12 hours
5. temperatureUpon cooling a slightly yellow and viscous solution
6. customwas obtained
7. customThis solution was dialysed (25 k MWCO regenerated cellulose) overnight against water
8. customfreeze-dried
9. customto obtain a white fluffy polymer

ORD 기록

ord-3e39440e2b3a4c0d8abc4fda76a9d008

출처 데이터셋

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08691517B2