Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → HCID 67075208, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | (9H-fluoren-9-yl)methyl (S)-3-(4-tert-butoxyphenyl)-1-(((S)-1,1-diethoxypropan-2-yl)(quinolin-8-ylmethyl)amino)-1-oxopropan-2-ylcarbamate | HCID 86698527 | — |
| 생성물 | HCID 67075208 | HCID 67075208 | 77% |
반응 단계
According to the procedure described in the synthesis method of Compound IV-1, (9H-fluoren-9-yl)methyl(S)-3-(4-tert-butoxyphenyl)-1-(((S)-1,1-diethoxypropan-2-yl)(quinolin-8-ylmethyl)amino)-1-oxopropan-2-ylcarbamate (Compound III-7) (2.41 g, 3.31 mmol) was treated with piperidine and the obtained residue was purified by silica gel column chromatography (eluent: n-hexane:ethyl acetate=chloroform:methanol=100:0 and 8:2) to obtain the title compound (1.29 g, 77%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08691819B2 |
| 출처 데이터셋 | uspto-grants-2014_04 |
| ORD ID | ord-20b85a54416f4b7fa9a45c3437510053 |
| 출처 메모 | uspto-grants-2014_04 |