Potassium Carbonate → Piperazin-1-yl(thiazol-2-yl)methanone
반응식
FC(F)(F)C([N:5]1[CH2:10][CH2:9][N:8]([C:11]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[O:12])[CH2:7][CH2:6]1)=O.C([O-])([O-])=O.[K+].[K+]>CO.O>[N:8]1([C:11]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[O:12])[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]1참가 물질
5
실험 절차
A solution of compound 7a (3.8 g, 0.013 mol) and K2CO3 (3.5 g, 0.026 mol) in MeOH (40 mL) and water (10 mL), was stirred for 4 h. The solid was collected by filtration and the solvent evaporated in vacuo to give compound 7b (6.12 g). MS m/z (M+H+) 198.1.
후처리
- filtrationThe solid was collected by filtration
- customthe solvent evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-466e29ef6079416289539543e0d36595
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08691805B2
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