HCID 86673423, 화합물 → HCID 86673426, 화합물

반응식

F[C:2]1[CH:16]=CC(F)=C[C:3]=1[CH2:4][P:5](=[O:12])([O:9][CH2:10][CH3:11])[O:6][CH2:7][CH3:8].[Br:18][C:19]1[N:24]=C(CBr)C=C[N:20]=1>>[CH2:7]([O:6][P:5]([CH2:4][C:3]1[CH:2]=[CH:16][N:24]=[C:19]([Br:18])[N:20]=1)(=[O:12])[O:9][CH2:10][CH3:11])[CH3:8]

참가 물질

반응물 2

HCID 86673423HCID 86673423, 화합물

HCID 86673424HCID 86673424, 화합물

생성물 1

HCID 86673426HCID 86673426, 화합물

실험 절차

Prepared according to the same procedure as diethyl 2,5-difluorobenzylphosphonate, starting with 2-bromo-4-(bromomethyl)pyrimidine. 1H NMR (500 MHz, DMSO-d6) δ 8.69-8.58 (m, 1H), 7.67-7.44 (m, 1H), 4.14-3.91 (m, 4H), 3.62-3.43 (m, 2H), 1.42-1.09 (m, 6H), Mass spec.: 310.1 (MH)+.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-782ddab5fabb4191987ea9fb3990eada
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08691821B2

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