HCID 69085480, 화합물 → HCID 86673429, 화합물

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Br[C:2]1C=NC=[C:6](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[F:17])[CH:7]=1.[Br:18][C:19]1[N:24]=C(CP(=O)(OCC)OCC)C=C[N:20]=1>>[Br:18][C:19]1[N:24]=[C:6](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[F:17])[CH:7]=[CH:2][N:20]=1

참가 물질

반응물 2

HCID 69085480HCID 69085480, 화합물

HCID 86673426HCID 86673426, 화합물

생성물 1

HCID 86673429HCID 86673429, 화합물

실험 절차

Prepared according to the same procedure as (E)-3-bromo-5-(2,5-difluorostyryl)pyridine, starting with diethyl (2-bromopyrimidin-4-yl)methylphosphonate. 1H NMR (500 MHz, DMSO-d6) δ 8.70 (d, J=5.2 Hz, 1H), 7.93 (d, J=16.2 Hz, 1H), 7.83 (ddd, J=9.3, 5.8, 3.2 Hz, 1H), 7.72 (d, J=5.2 Hz, 1H), 7.46 (d, J=16.2 Hz, 1H), 7.43-7.30 (m, 2H), Mass spec.: 299.1 (MH)+.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-f83b5e6085f7451eacb643386cae0bb7
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08691821B2

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