Cyclobutanone → N-cyclobutylidene-1-(4-methoxyphenyl)methanamine

HRID 2362712노트

반응식

HRID 2362712 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH2:10])=[CH:5][CH:4]=1.[C:11]1(=O)[CH2:14][CH2:13][CH2:12]1>C(OCC)C>[C:11]1(=[N:10][CH2:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH2:14][CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 14496CyclobutanoneHCID 754524-Methoxybenzylamine

생성물 1

HCID 58513739N-cyclobutylidene-1-(4-methoxyphenyl)methanamine

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of (4-methoxyphenyl)methanamine (9.26 mL, 71.3 mmol) and cyclobutanone (5.35 mL, 71.3 mmol) in anhydrous ethyl ether (70 mL) was treated with activated 4 angstrom molecular sieves (2.5 g). The mixture was stirred vigorously for 16 hours at ambient temperature. The reaction mixture was filtered, and the sieves were washed with ethyl ether. The filtrate was concentrated under reduced pressure with no heat. The title compound was stored under nitrogen and used without further purification. MS DCI(+) m/z 190.3 [M+H]+.

후처리

  1. filtrationThe reaction mixture was filtered
  2. washthe sieves were washed with ethyl ether
  3. concentrationThe filtrate was concentrated under reduced pressure with no heat
  4. customused without further purification

출처 및 근거

ORD 기록
ord-f1d9da33223342feba165a1c3aef4ef6
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691810B2

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