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Dihydro-3(2H)-thiophenone → 3-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)tetrahydrothiophen-3-ol

HRID 2362744
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HRID 2362744 반응식
[Cl:1][C:2]1[C:3]([C:27]2[S:31][CH:30]=[N:29][CH:28]=2)=[C:4]2[CH:10]=[C:9]([C:11]3[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=3)[N:8]([S:17]([C:20]3[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=3)(=[O:19])=[O:18])[C:5]2=[N:6][CH:7]=1.C([Li])CCC.[S:37]1[CH2:41][CH2:40][C:39](=[O:42])[CH2:38]1>O1CCCC1>[Cl:1][C:2]1[C:3]([C:27]2[S:31][C:30]([C:39]3([OH:42])[CH2:40][CH2:41][S:37][CH2:38]3)=[N:29][CH:28]=2)=[C:4]2[CH:10]=[C:9]([C:11]3[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=3)[N:8]([S:17]([C:20]3[CH:21]=[CH:22][C:23]([CH3:24])=[CH:25][CH:26]=3)(=[O:19])=[O:18])[C:5]2=[N:6][CH:7]=1
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참가 물질

5

반응물 3

HCID 61252Dihydro-3(2H)-thiophenoneHCID 670035295-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazoleHCID 178418339Butyllithium

생성물 1

HCID 670029113-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)tetrahydrothiophen-3-ol

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

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온도
-78 °C

실험 절차

A solution of Example 144A (0.095 g, 0.202 mmol) in tetrahydrofuran (2.5 mL) was cooled to −78° C. and treated with n-butyllithium (2.45 M in hexanes, 0.173 mL, 0.424 mmol) dropwise over 5 minutes. The reaction was stirred at −78° C. for 20 minutes, and dihydrothiophen-3(2H)-one (0.033 mL, 0.384 mmol) was added. The reaction was stirred 60 minutes at −78° C. and was quenched by addition of saturated aqueous sodium bicarbonate solution. The mixture was allowed to warm to ambient temperature and was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The concentrate was purified by flash chromatography on a silica gel column, eluting with 1% methanol in dichloromethane, to provide the title compound. MS ESI(+) m/z 572.3 [M+H]+.

후처리

  1. stirringThe reaction was stirred 60 minutes at −78° C.
  2. customwas quenched by addition of saturated aqueous sodium bicarbonate solution
  3. temperatureto warm to ambient temperature
  4. extractionwas extracted with ethyl acetate
  5. washThe organic layer was washed with brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure
  9. customThe concentrate was purified by flash chromatography on a silica gel column
  10. washeluting with 1% methanol in dichloromethane

출처 및 근거

ORD 기록
ord-59e4be98a1ab43b8b0cb99f5dd7a6f13
출처 데이터셋
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08691810B2

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