Chlorosuccinimide → 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone

HRID 2362805노트

반응식

HRID 2362805 반응식
[Cl:1]N1C(=O)CCC1=O.[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]>CN(C=O)C>[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([Cl:1])[C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 594970761-butyl-4-hydroxy-1H-pyridine-2-one

생성물 1

HCID 594970741-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone수율 83%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N-Chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D5 (2.0 g, 11.96 mmol) in DMF (30 ml). The reaction mixture was stirred overnight at room temperature and was then concentrated in vacuo. The crude residue was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent) to yield intermediate D6 (2.0 g, 83%).

후처리

  1. concentrationwas then concentrated in vacuo
  2. customThe crude residue was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent)

출처 및 근거

ORD 기록
ord-32c1fd10ba544846ad7a947bf40dba39
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691849B2

반응 노트

불러오는 중…