Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-(3-methyl-1H-pyrazol-1-yl)-4(3H)-quinazolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4,4-Dimethoxy-2-butanone | HCID 228548 | — |
| 반응물 | 2-Hydrazinyl-3,4-dihydroquinazolin-4-one | HCID 135449613 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(3-methyl-1H-pyrazol-1-yl)-4(3H)-quinazolinone | HCID 135782151 | — |
반응 단계
35.2 g (0.2 mole) of 2-hydrazino-4(3H)-quinazolinone, 500 ml of ethanol and 31.68 g (0.24 mole) of 4,4-dimethoxy-butan-2-one are boiled under reflux for 4.5 hours. The initial suspension has then dissolved. The same volume of 2 N HCl at 50° is added at 50°, whereupon a precipitate soon forms. After warming at 50° for a total of 40 minutes, the 2-(3-methyl-1H-pyrazol-1-yl)-4(3H)-quinazolinone is isolated by filtration with suction. The crude product (35.9 g of melting point 162° to 165° C.) is recrystallized from ethanol and then has a melting point of 165° to 166° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04644000 |
| 출처 데이터셋 | uspto-grants-1987_02 |
| ORD ID | ord-2d330b0118dd4d29bb8bc8721630b65a |
| 출처 메모 | uspto-grants-1987_02 |