2-Cyanoethanethioamide → HCID 178510482, 화합물

HRID 2362819노트

반응식

HRID 2362819 반응식
[N:1]([CH2:4][CH2:5][O:6][C:7]1[CH:18]=[CH:17][C:10]([CH:11]=[C:12]([C:15]#[N:16])[C:13]#[N:14])=[CH:9][CH:8]=1)=[N+:2]=[N-:3].[C:19]([CH2:21][C:22]([NH2:24])=[S:23])#[N:20]>C(O)C>[NH2:16][C:15]1[C:12]([C:13]#[N:14])=[C:11]([C:10]2[CH:17]=[CH:18][C:7]([O:6][CH2:5][CH2:4][N:1]=[N+:2]=[N-:3])=[CH:8][CH:9]=2)[C:21]([C:19]#[N:20])=[C:22]([SH:23])[N:24]=1

참가 물질

4

반응물 2

HCID 14162772-CyanoethanethioamideHCID 86624335[4-(2-Azidoethoxy)benzylidene]malononitrile

생성물 1

HCID 178510482HCID 178510482, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2.39 g (9.98 mmol) of the compound from Example 37A and 2.50 g (24.92 mmol) of cyanothioacetamide in 100 ml of ethanol is stirred at +78° C. for 6 h. After cooling to RT and a further 12 h of standing without stirring, the reaction mixture is concentrated using a rotary evaporator. The residue is recrystallized from about 30 ml of ethanol. The resulting precipitate is filtered off with suction and washed twice with in each case 10 ml of methyl tert-butyl ether.

후처리

  1. concentrationthe reaction mixture is concentrated
  2. customa rotary evaporator
  3. customThe residue is recrystallized from about 30 ml of ethanol
  4. filtrationThe resulting precipitate is filtered off with suction
  5. washwashed twice with in each case 10 ml of methyl tert-butyl ether

출처 및 근거

ORD 기록
ord-b01065bebd994833b94fcaac08b370c1
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691850B2

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