Ethanol → 3,7-dihydro-8-methyl-3-propyl-1H-purine-2,6-dione
반응식
[NH2:1][C:2]1[C:3](=[O:13])[NH:4][C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=1[NH2:8].[CH2:14](O)[CH3:15]>C(O)(=O)C>[CH3:14][C:15]1[NH:1][C:2]2[C:3](=[O:13])[NH:4][C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=2[N:8]=1참가 물질
4
실험 절차
A solution of 22.6 g of 5,6-diamino-1-propyl-2,4-(1H,3H)-pyrimidinedione in 50 ml of acetic acid was refluxed for 2 hours. 30 ml of ethanol was added. The received crystals were filtered off. Yield 19.8 g. The amide was refluxed in 80 ml of 2N NaOH for 2 hours and then neutralized with 5N HCl. The crystals were filtered off and recrystallized from 2.1 l ethanol. Yield 9.8 g (38%) (XXXXVI) NMR (see Table I).
후처리
- filtrationThe received crystals were filtered off
- temperatureThe amide was refluxed in 80 ml of 2N NaOH for 2 hours
- filtrationThe crystals were filtered off
- customrecrystallized from 2.1 l ethanol
출처 및 근거
- ORD 기록
- ord-53f91be1b9e8435dbf46f9dfd95ed382
- 출처 데이터셋
- uspto-grants-1987_02
- 특허 번호
- US04644001
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