Ammonium Chloride → 3-cyclobutylphenol

HRID 2363146노트

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HRID 2363146 반응식
[CH:1]1([C:5]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11]C)[CH:6]=2)[CH2:4][CH2:3][CH2:2]1.[Cl-].[NH4+]>C(Cl)Cl>[CH:1]1([C:5]2[CH:6]=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=2)[CH2:2][CH2:3][CH2:4]1

참가 물질

4

반응물 2

HCID 25517Ammonium ChlorideHCID 58319227HCID 58319227, 화합물

생성물 1

HCID 179184093-cyclobutylphenol수율 71%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a suspension of 1-cyclobutyl-3-methoxy-benzene (155 mg, 0.95 mmol) in CH2Cl2 (2 mL) was added dropwise 1.0M-BBr2 (1.05 mL, 1.05 mmol) at 0° C. The mixture was stirred for 1 hour at 0° C., treated with saturated ammonium chloride, and then extracted with CH2Cl2. The organic layer was dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by column chromatography to give 3-cyclobutyl-phenol (100 mg, 71%).

후처리

  1. additionwas added dropwise 1.0M-BBr2 (1.05 mL, 1.05 mmol) at 0° C
  2. extractionextracted with CH2Cl2
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe crude product was purified by column chromatography

출처 및 근거

ORD 기록
ord-e4862231c4844d1e8c605f08681077f5
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691855B2

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