홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Carbonate → 7-(1-ethoxy-carbonylethyl)oxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

HRID 236342
노트
인쇄 미리보기

반응식

HRID 236342 반응식
[OH:1][C:2]1[CH:19]=[CH:18][C:5]2[C:6](=[O:17])[C:7]([C:10]3[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=3)=[CH:8][O:9][C:4]=2[CH:3]=1.Br[CH:21]([CH3:27])[C:22]([O:24][CH2:25][CH3:26])=O.C(=O)([O-])[O-:29].[K+].[K+]>CN(C)C=O>[CH2:25]([O:24][CH:22]([O:1][C:2]1[CH:19]=[CH:18][C:5]2[C:6](=[O:17])[C:7]([C:10]3[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=3)=[CH:8][O:9][C:4]=2[CH:3]=1)[CH:21]=[C:27]=[O:29])[CH3:26]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 79040Ethyl 2-bromopropionateHCID 5281708Daidzein

생성물 1

HCID 867413097-(1-ethoxy-carbonylethyl)oxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one수율 54.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

A mixture of 4.0 g of 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 3.42 g of ethyl 2-bromopropionate, 60 ml of dimethylformamide and 4.3 g of potassium carbonate was stirred well with heating at 80° C. for 2 hours, poured into ice water and extracted with ethyl acetate. The extract was washed with water and concentrated and the residue was recrystallized from dichloroethane to give 3.0 g of 7-(1-ethoxy- carbonylethyl)oxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one as white crystals. m.p. 172°-173° C.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water
  3. concentrationconcentrated
  4. customthe residue was recrystallized from dichloroethane

출처 및 근거

ORD 기록
ord-122f3f1eb7e848a48d97ae0877aab56c
출처 데이터셋
uspto-grants-1987_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04644012

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트