6-(6-{[(1,1-Dimethylethoxy)carbonyl]amino}pyridin-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid → 6-(Furan-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid

반응식

[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([C:15]([O:17]CC)=[O:16])[N:14]=2)[CH:11]=1.CC(C)(OC(NC1N=C(C2C=CC3N(C=C(C(O)=O)N=3)C=2)C=CC=1)=O)C>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=2)[CH:11]=1

참가 물질

반응물 2

HCID 441249406-(6-{[(1,1-Dimethylethoxy)carbonyl]amino}pyridin-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid

HCID 44136206Ethyl 6-(furan-2-yl)imidazo[1,2-a]pyridine-2-carboxylate

생성물 1

HCID 441250756-(Furan-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid수율 74.9%

실험 절차

384 mg of ethyl 6-(furan-2-yl)imidazo[1,2-a]pyridine-2-carboxylate are saponified under conditions similar to those described for the preparation of Intermediate 11 (step 11.3) to give 256 mg of 6-(furan-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid.

출처 및 근거

ORD 기록: ord-81470262725b4124bb1ae354f0d2e30b
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08691990B2

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