Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Kojic Acid → 5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Kojic Acid | HCID 3840 | — |
| 반응물 | Benzyl Chloride | HCID 7503 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Methanol--water (1/1) | HCID 22242641 | — |
| 생성물 | 5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one | HCID 901598 | — |
반응 단계
To a stirred solution of 17 g (0.12 mole) of kojic acid and 5.1 g (0.13 mole) of sodium hydroxide in 190 ml of 10:1 (by volume) methanol-water was added dropwise 17.5 g (0.14 mole) of benzyl chloride. After 4.5 hours at reflux, the mixture was allowed to cool and was poured into 200 ml of ice-water. The resultant solid was collected, washed with water, and dried, giving 22.4 g of analytically pure title compound, m.p. 128°-130°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04644071 |
| 출처 데이터셋 | uspto-grants-1987_02 |
| ORD ID | ord-2a0208667b7d42f3b2868acc683b8753 |
| 출처 메모 | uspto-grants-1987_02 |