3-Propoxypropylamine → 7-[(4-Fluorophenyl)methyl]-4-hydroxy-2-oxo-N-[3-(propyloxy)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxamide

HRID 2364327

반응식

HRID 2364327 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13]([OH:25])=[C:14]([C:20](OCC)=[O:21])[C:15](=[O:19])[NH:16]3)=[N:11][CH:10]=2)=[CH:4][CH:3]=1.[CH2:26]([O:29][CH2:30][CH2:31][CH2:32][NH2:33])[CH2:27][CH3:28]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13]([OH:25])=[C:14]([C:20]([NH:33][CH2:32][CH2:31][CH2:30][O:29][CH2:26][CH2:27][CH3:28])=[O:21])[C:15](=[O:19])[NH:16]3)=[N:11][CH:10]=2)=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 855793-PropoxypropylamineHCID 54729997Ethyl 7-[(4-Fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

생성물 1

HCID 694808507-[(4-Fluorophenyl)methyl]-4-hydroxy-2-oxo-N-[3-(propyloxy)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxamide

실험 절차

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 3-propoxypropylamine employing methods similar to those described in Example 2 and was obtained a white solid: 1H NMR (d6-DMSO) δ 11.83 (1H, br s), 10.26 (1H, br s), 8.48 (1H, br s), 7.43 (1H, s), 7.30-7.26 (2H, m), 7.16-7.11 (2H, m), 4.09 (2H, s), 3.42-3.38 (4H, m), 3.30-3.28 (2H, m), 1.76-1.71 (2H, m), 1.49 (2H, q, J=7 Hz), 0.83 (3H, t, J=7.3 Hz); HRMS calcd for C22H24FN3O4+H+: 414.1829. Found 414.1844.

후처리

  1. customwas obtained a white solid

출처 및 근거

ORD 기록
ord-fe5eb4a468b44b5691848d0df88b91cd
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691991B2

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