Ammonia → tert-butyl 4-[(2S)-3-amino-2-hydroxy-propyl]piperazine-1-carboxylate

HRID 2364687노트

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HRID 2364687 반응식
[O:1]1[CH2:3][C@H:2]1[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][CH2:6]1.[NH3:18]>C(O)C>[NH2:18][CH2:3][C@H:2]([OH:1])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][CH2:6]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 11010131Tert-butyl 4-[[(2R)-oxiran-2-yl]methyl]piperazine-1-carboxylate

생성물 1

HCID 7144880tert-butyl 4-[(2S)-3-amino-2-hydroxy-propyl]piperazine-1-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
50 °C

실험 절차

Tert-butyl 4-[[(2R)-oxiran-2-yl]methyl]piperazine-1-carboxylate 7b (3.55 g, 14.70 mmol) was dissolved in 40 mL of ethanol followed by the addition of 40 mL of aqueous ammonia, stirred for 12 hours. The resulting solution was heated to 50° C. and stirred for another 1 hour, then concentrated under reduced pressure to obtain the crude title compound tert-butyl 4-[(2S)-3-amino-2-hydroxy-propyl]piperazine-1-carboxylate 7c (3.40 g) as a light yellow solid, which was used in the next step without further furification.

후처리

  1. stirringstirred for another 1 hour
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a6815d09190c420f9a36eab9d568d9cb
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691822B2

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