Ammonia → Tert-butyl 4-[(2R)-3-amino-2-hydroxy-propyl]piperazine-1-carboxylate

HRID 2364706노트

반응식

HRID 2364706 반응식
[O:1]1[CH2:3][C@@H:2]1[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][CH2:6]1.[NH3:18]>C(O)C>[NH2:18][CH2:3][C@@H:2]([OH:1])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][CH2:6]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 10977626(S)-1-Boc-4-(oxiran-2-ylmethyl)piperazine

생성물 1

HCID 7009319Tert-butyl 4-[(2R)-3-amino-2-hydroxy-propyl]piperazine-1-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Tert-butyl 4-[[(2S)-oxiran-2-yl]methyl]piperazine-1-carboxylate 20a (9.20 g, 38 mmol) was dissolved in 60 mL of ethanol followed by the addition of 50 mL of aqueous ammonia. The reaction solution was stirred for 12 hours. The reaction solution was concentrated under reduced pressure to obtain the crude title compound tert-butyl 4-[(2R)-3-amino-2-hydroxy-propyl]piperazine-1-carboxylate 20b (9 g, as a white solid), which was used in the next step without further furification.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-363af2e17a5f48d398d140b3d74d5a9f
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08691822B2

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