Tert-butyl 3-hexadecanoyloxyoctadecanoate → 3-Hexadecanoyloxyoctadecanoic acid

HRID 236476

반응식

HRID 236476 반응식
[C:1]([O:18][CH:19]([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]>FC(F)(F)C(O)=O>[C:1]([O:18][CH:19]([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:20][C:21]([OH:23])=[O:22])(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

3

반응물 1

HCID 20216792Tert-butyl 3-hexadecanoyloxyoctadecanoate

생성물 1

HCID 134890283-Hexadecanoyloxyoctadecanoic acid수율 88.5%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

To tert-butyl 3-hexadecanoyloxyoctadecanoate (156 g) was added trifluoroacetic acid (200 ml) at 0° C. After the temperature of the mixture was reached to ambient temperature, the resulting solution was allowed to stand at the same temperature for 3 hours. Excess trifluoroacetic acid was distilled off under reduced pressure. The residue was taken up in benzene and the solvent was evaporated off. This operation was repeated twice to remove trifluoroacetic acid completely. The residue was recrystallized from petroleum ether in refrigerator to afford crystals of 3-hexadecanoyloxyoctadecanoic acid (125 g).

후처리

  1. customwas reached to ambient temperature
  2. distillationExcess trifluoroacetic acid was distilled off under reduced pressure
  3. customthe solvent was evaporated off
  4. customto remove trifluoroacetic acid completely
  5. customThe residue was recrystallized from petroleum ether in refrigerator

출처 및 근거

ORD 기록
ord-fb118060bea84f088a0355de05b73f24
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04643990

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