(Piperidine-1-yl)-acetic acid-benzylester → Piperidin-1-yl-acetic acid

HRID 2364932노트

반응식

HRID 2364932 반응식
C([O:8][C:9](=[O:17])[CH2:10][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[N:11]1([CH2:10][C:9]([OH:17])=[O:8])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

4

반응물 1

HCID 11379293(Piperidine-1-yl)-acetic acid-benzylester

생성물 1

HCID 201097Piperidin-1-yl-acetic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

10.4 g (44 mMol) (piperidine-1-yl)-acetic acid-benzylester 9 was stirred with 0.25 g Pd/C (5%) in 100 ml Methanol at RT. Under normal pressure, the reaction mixture was reduced (hydrated) with H2. After having removed the catalyst, the solution was evaporated and the residue was resuspended in EtOAc and filtered off.

후처리

  1. customAfter having removed the catalyst
  2. customthe solution was evaporated
  3. filtrationfiltered off

출처 및 근거

ORD 기록
ord-3c06d4dd3ff941a0b0af65238a7c5a8d
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697604B2

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