Chlorosuccinimide → 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone

HRID 2364942노트

반응식

HRID 2364942 반응식
[Cl:1]N1C(=O)CCC1=O.[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]>CN(C=O)C>[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([Cl:1])[C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 594970761-butyl-4-hydroxy-1H-pyridine-2-one

생성물 1

HCID 594970741-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone수율 83%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N-chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D2 (2.0 g, 11.96 mmol) in DMF (30 ml). The mixture was stirred overnight at r.t. and was then concentrated in vacuo. The crude product was purified by column chromatography (silica gel; 0-5% MeOH/DCM as eluent) to yield intermediate D3 (2.0 g, 83%).

후처리

  1. concentrationwas then concentrated in vacuo
  2. customThe crude product was purified by column chromatography (silica gel; 0-5% MeOH/DCM as eluent)

출처 및 근거

ORD 기록
ord-08a2d1aec01d453b9c46bd1e484debd9
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697689B2

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