dibenzyl N-(N-butanoyl-L-valyl)-L-glutamate → N-(N-butanoyl-L-valyl)-L-glutamic acid

HRID 236499노트

반응식

HRID 236499 반응식
[C:1]([NH:6][C@H:7]([C:11]([NH:13][C@H:14]([C:27]([O:29]CC1C=CC=CC=1)=[O:28])[CH2:15][CH2:16][C:17]([O:19]CC1C=CC=CC=1)=[O:18])=[O:12])[CH:8]([CH3:10])[CH3:9])(=[O:5])[CH2:2][CH2:3][CH3:4]>CO.[Pd]>[C:1]([NH:6][C@H:7]([C:11]([NH:13][C@H:14]([C:27]([OH:29])=[O:28])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[O:12])[CH:8]([CH3:9])[CH3:10])(=[O:5])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 1

HCID 54213157dibenzyl N-(N-butanoyl-L-valyl)-L-glutamate

생성물 1

HCID 53954075N-(N-butanoyl-L-valyl)-L-glutamic acid수율 87.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of dibenzyl N-(N-butanoyl-L-valyl)-L-glutamate (613 mg) and palladium black (50 mg) in methanol (50 ml) was subjected to catalytic hydrogenation under atmospheric pressure. After the reaction mixture was filtered, the filtrate was concentrated under reduced pressure to give a residue which was recrystallized from petroleum ether to afford N-(N-butanoyl-L-valyl)-L-glutamic acid as crystals (343 mg).

후처리

  1. filtrationAfter the reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customto give a residue which
  4. customwas recrystallized from petroleum ether

출처 및 근거

ORD 기록
ord-a41bdb0ceab343c782887b6261246620
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04643990

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