Cyclopentylamine → N-(Cyclopentylaminocarbonyl)-2,3-dichlorobenzenesulfonamide

HRID 236519노트

반응식

HRID 236519 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([N:12]=[C:13]=[O:14])(=[O:11])=[O:10].[CH:15]1([NH2:20])[CH2:19][CH2:18][CH2:17][CH2:16]1>C(#N)C>[CH:15]1([NH:20][C:13]([NH:12][S:9]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([Cl:8])[C:2]=2[Cl:1])(=[O:10])=[O:11])=[O:14])[CH2:19][CH2:18][CH2:17][CH2:16]1

참가 물질

4

반응물 2

HCID 2906CyclopentylamineHCID 138527082,3-Dichlorobenzenesulfonyl isocyanate

생성물 1

HCID 13852709N-(Cyclopentylaminocarbonyl)-2,3-dichlorobenzenesulfonamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To 20 mL of the acetonitrile solution containing 2,3-dichlorobenzenesulfonyl isocyanate, prepared as described in the previous example, was added 2.5 mL of cyclopentylamine. This mixture was allowed to sit overnight. The solid precipitate was filtered off and triturated with 5 mL of acetonitrile. Filtration and drying afforded 5.0 g of the title compound as an off-white solid, m.p. 202°-207° C.; NMR (DMSO-d6): δ1.1-1.8 (m, 8H), 3.7 (m, 1H), 6.5 (br d, 1H), 7.6 (t, 1H), 7.9 (dd, 1H), 8.0 (dd, 1H), 10.8 (br s, 1H); IR (nujol): 3343, 1660, 1375, 1170 cm-1.

후처리

  1. customprepared
  2. filtrationThe solid precipitate was filtered off
  3. customtriturated with 5 mL of acetonitrile
  4. filtrationFiltration
  5. customdrying

출처 및 근거

ORD 기록
ord-06e6ed168fd14655bebf3edf8d5d11c7
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04645527

반응 노트

불러오는 중…