2-Amino-4-methoxy-6-methyl-1,3,5-triazine → 4-Bromo-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-aminocarbonyl]-3-thiophenesulfonamide
반응식
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([CH3:10])[N:3]=1.[Br:11][C:12]1[C:13]([S:17]([N:20]=[C:21]=[O:22])(=[O:19])=[O:18])=[CH:14][S:15][CH:16]=1>O1CCCC1>[Br:11][C:12]1[C:13]([S:17]([NH:20][C:21]([NH:1][C:2]2[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([CH3:10])[N:3]=2)=[O:22])(=[O:18])=[O:19])=[CH:14][S:15][CH:16]=1참가 물질
4
반응 조건
- 온도
- 10 °C
실험 절차
To 1.1 g of 2-amino-4-methoxy-6-methyl-1,3,5-triazine in 20 ml of tetrahydrofuran was added 2 g of 4-bromo-3-thiophenesulfonyl isocyanate in 5 ml of tetrahydrofuran. The mixture was then stirred and warmed on a steam bath for 15 minutes and allowed to stir at ambient temperature for 70 hours. It was then heated to reflux for 2 hours, cooled to 10° C., filtered and the filtrate evaporated. The residual oil was triturated to yield the desired product as a solid which after recrystallization from acetonitrile melted at 180°-183°, yield 1.5 g.