Ammonia → tert-Butyl 4-amino-4-(aminomethyl)piperidine-1-carboxylate

HRID 2365544노트

반응식

HRID 2365544 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([CH2:21][NH2:22])([NH:14]C(=O)C(F)(F)F)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].N>CO>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][C:11]([NH2:14])([CH2:21][NH2:22])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 866419114-Aminomethyl-4-(2,2,2-trifluoro-acetylamino)-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 22975818tert-Butyl 4-amino-4-(aminomethyl)piperidine-1-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
80 °C

실험 절차

To a solution of 4-aminomethyl-4-(2,2,2-trifluoro-acetylamino)-piperidine-1-carboxylic acid tert-butyl ester in MeOH (70 ml) is added a 30% aqueous solution of ammonia (70 ml) and the reaction mixture is stirred at 80° C. overnight. The reaction mixture is concentrated in vacuo to 4-Amino-4-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester as a brown oil that is used crude without further purification; [M+H]+ 230.

후처리

  1. concentrationThe reaction mixture is concentrated in vacuo to 4-Amino-4-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester as a brown oil that
  2. customwithout further purification

출처 및 근거

ORD 기록
ord-7993df4947504d45a4c89791662e599f
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697687B2

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