methyl 1H-indole-4-carboxylate → 1-Isopropylcarbamoyl-1H-indole-4-carboxylic acid
반응식
[CH:1]([NH:4][C:5](=[O:16])NC1C=C(C=CN=1)C(O)=O)([CH3:3])[CH3:2].NC1C=C(C=CN=1)C(OCC)=O.[NH:29]1[C:37]2[CH:36]=[CH:35][CH:34]=[C:33]([C:38]([O:40]C)=[O:39])[C:32]=2[CH:31]=[CH:30]1>>[CH:1]([NH:4][C:5]([N:29]1[C:37]2[CH:36]=[CH:35][CH:34]=[C:33]([C:38]([OH:40])=[O:39])[C:32]=2[CH:31]=[CH:30]1)=[O:16])([CH3:3])[CH3:2]참가 물질
4
실험 절차
This compound is prepared analogously to Intermediate Y by replacing ethyl 2-aminoisonicotinate in step 1 with methyl indol-4-carboxylate; [M+H]+ 247
출처 및 근거
- ORD 기록
- ord-a710a4356e5a4144838c19e55d070e62
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08697687B2
반응 노트
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