Ammonia → 4-Amino-1-(1-phenyl-ethyl)-piperidine-4-carbonitrile

HRID 2365584노트

반응식

HRID 2365584 반응식
[C:1]1([CH:7]([N:9]2[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].[NH4+:17].[NH3:18].[C-:19]#N.[Na+]>O>[NH2:17][C:12]1([C:19]#[N:18])[CH2:13][CH2:14][N:9]([CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH3:8])[CH2:10][CH2:11]1

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 8929Sodium CyanideHCID 25517Ammonium ChlorideHCID 119596271-(1-Phenylethyl)piperidin-4-one

생성물 1

HCID 671207084-Amino-1-(1-phenyl-ethyl)-piperidine-4-carbonitrile

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a mixture of 1-(1-phenyl-ethyl)-piperidin-4-one (10.9 g, 53.6 mmol), ammonium chloride (4.3 g, 80.4 mmol) and 30% aqueous ammonia solution (30 ml) in water (30 ml) at room temperature is added sodium cyanide (4.0 g, 81.6 mmol) portion wise. The reaction mixture is stirred at room temperature for 18 hours, then diluted with water and extracted with DCM. The organic phase is washed with brine, dried over Na2SO4, filtered and concentrated in vacuo to obtain 4-Amino-1-(1-phenyl-ethyl)-piperidine-4-carbonitrile as a brown oil; [M+H]+ 230.

후처리

  1. extractionextracted with DCM
  2. washThe organic phase is washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-88754d1a6a7141ffa9317a57c3229610
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697687B2

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