Methylamine → 1-{3-[2-(2-Methoxyethoxy)ethoxy]phenyl}-2-(methylamino)ethanol
반응식
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[C:11]([CH:15]2[CH2:17][O:16]2)[CH:12]=[CH:13][CH:14]=1.[CH3:18][NH2:19]>CO>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[C:11]([CH:15]([OH:16])[CH2:17][NH:19][CH3:18])[CH:12]=[CH:13][CH:14]=1참가 물질
4
실험 절차
A solution of 1.78 g of 2-{3-[2-(2-methoxyethoxy)ethoxy]phenyl}oxirane in 30 ml of 2.0 M methylamine in methanol is stirred at room temperature overnight, then concentrated under reduced pressure. Flash chromatography of the residue on silica using 5-7% methanolic ammonia in CH2Cl2 affords 809 mg of the title compound as a colorless oil.
후처리
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-bb509f1b8640430d8cc33626b71a7076
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06852731B2
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