Trimethylamine → 2,3-Epoxypropyltrimethylammonium bromide
반응식
[CH3:1][N:2]([CH3:4])[CH3:3].[CH2:5]([CH:7]1[O:9][CH2:8]1)[Br:6]>CC(C)=O>[Br-:6].[O:9]1[CH2:8][CH:7]1[CH2:5][N+:2]([CH3:4])([CH3:3])[CH3:1]참가 물질
4
반응 조건
- 온도
- 10 °C
실험 절차
A flask equipped with a sparger, mechanical stirrer, thermometer and efficiency condenser was charged with acetone (500 milliliters) at ambient temperature. Trimethylamine (58 grams, 0.98 mol) was charged into the solution. The pot was cooled to 10° C. and epibromohydrin (137 grams, 1.0 mol) was added dropwise over a 1 hour period. The resultant cloudy solution was allowed to slowly rise to ambient temperature and stand for 60 hours. Precipitate was collected by filtration washed with acetone (60 milliliters) and dried yielding a colorless crystalline product (179.4 grams, 94%).
후처리
- customA flask equipped with a sparger, mechanical stirrer, thermometer and efficiency condenser
- customto slowly rise to ambient temperature
- filtrationPrecipitate was collected by filtration
- washwashed with acetone (60 milliliters)
- customdried
출처 및 근거
- ORD 기록
- ord-b855363253404447b1c1db1f70ea42fa
- 출처 데이터셋
- uspto-grants-1987_02
- 특허 번호
- US04645794
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