2-Iodoxybenzoic acid → HCID 62501749, 화합물

HRID 2366189노트

반응식

HRID 2366189 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[S:10][CH:11]=[C:12]([CH2:14][OH:15])[N:13]=1.I(C1C=CC=CC=1C(O)=O)(=O)=O>CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[S:10][CH:11]=[C:12]([CH:14]=[O:15])[N:13]=1

참가 물질

4

반응물 2

HCID 1087942-Iodoxybenzoic acidHCID 39347891HCID 39347891, 화합물

생성물 1

HCID 62501749HCID 62501749, 화합물수율 93.1%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
70 °C

실험 절차

To a stirred solution of (2-(2-chloro-6-fluorophenyl)thiazol-4-yl)methanol (5.8 g, 24 mmol) in EtOAc (200 mL) at room temperature was added 2-iodoxybenzoic acid (12.5 g, 44.6 mmol). The resulting mixture was heated at 70° C. for 18 hours. After cooling to room temperature, the residual solid was removed via filtration and the filtrate was concentrated under reduced pressure to give the crude desired product as a white solid (5.4 g, 93% yield) which was used in the next step without further purification.

후처리

  1. temperatureAfter cooling to room temperature
  2. customthe residual solid was removed via filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-bf8dfd389e81434c8fe3c0e4a7b4c9fa
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697708B2

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