Cesium carbonate → {3,5-Dichloro-4-[4-(6-methyl-pyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-phenyl}-methanol

A mixture of [3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridin-2-yl)-phenyl]-methanol (0.063 g, 0.18 mmol), 4-amino-6-methylpyrimidine (0.022 g, 0.20 mmol), Pd2(dba)3 (0.003 g, 3.6 mmol), XantPhos (0.003 g, 5.0 pmol) and cesium carbonate (0.117 g, 0.36 mmol) in dioxane (1.1 mL) was degassed with nitrogen and subjected to microwave irradiation at 150° C. for 30 minutes. Further 4-amino-6-methylpyrimidine (0.011 g, 0.10 mmol), Pd2(dba)3 (0.006 g, 7.2 pmol), and XantPhos (0.006 g, 10.0 pmol) were added and the mixture subjected to further microwave irradiation at 150° C. for 60 minutes. The reaction mixture was diluted with MeOH and passed through a nylon filter. The filtrate was concentrated under reduced pressure then loaded onto an Isolute® SCX-2 cartridge which was washed with MeOH and the product eluted with 2M ammonia in MeOH. The eluent was concentrated under reduced pressure and the resultant residue was purified by silica gel flash chromatography eluting with 0-100% EtOAc in DCM to give the desired compound as a yellow solid (0.030 g, 40% yield). 1H NMR (300 MHz, CDCl3): δ 8.68 (s, 1H), 8.42 (br s, 1H), 8.18-8.04 (m, 1H), 7.77 (d, J=5.7 Hz, 1H), 7.50 (s, 2H), 4.72 (s, 2H), 2.55 (s, 3H). LCMS (Method C): RT=2.90 min, m/z: 418 [M+H+].

1. customwas degassed with nitrogen
2. customirradiation at 150° C. for 30 minutes
3. customthe mixture subjected to further microwave irradiation at 150° C. for 60 minutes
4. filtrationfilter
5. concentrationThe filtrate was concentrated under reduced pressure
6. washwas washed with MeOH
7. washthe product eluted with 2M ammonia in MeOH
8. concentrationThe eluent was concentrated under reduced pressure
9. customthe resultant residue was purified by silica gel flash chromatography
10. washeluting with 0-100% EtOAc in DCM

ORD 기록

ord-bb7826d9f4264efb90ed6fa3dfe43b8d

출처 데이터셋

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08697708B2