3,4-Dimethoxybenzeneacetonitrile → HCID 11965578, 화합물

HRID 2366395노트

반응식

HRID 2366395 반응식
[CH2:1]([N:8]1[C:12]([CH:13]=O)=[CH:11][N:10]=[C:9]1[S:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[CH2:22][C:23]#[N:24]>>[CH2:1]([N:8]1[C:12](/[CH:13]=[C:22](/[C:21]2[CH:25]=[CH:26][C:27]([O:28][CH3:29])=[C:19]([O:18][CH3:17])[CH:20]=2)\[C:23]#[N:24])=[CH:11][N:10]=[C:9]1[S:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 3434141-benzyl-2-(methylsulfanyl)-1H-imidazole-5-carbaldehyde

생성물 1

HCID 11965578HCID 11965578, 화합물수율 92.4%

실험 절차

1-Benzyl-2-(methylsulfanyl)-1H-imidazole-5-carbaldehyde (465 mg) was condensed with 3,4-dimethoxybenzyl cyanide (354 mg) through Method A (production step 2), to thereby yield the target product (yield: 723 mg, 92%).

출처 및 근거

ORD 기록
ord-6ab439e38ca54c608883a8ecbfac0568
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697742B2

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