Methylamine → HCID 10149078, 화합물
반응식
[CH3:1][NH2:2].[F:3][C:4]1[CH:5]=[C:6]([CH:12]2[CH2:14][O:13]2)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]>ClCCl>[CH3:1][NH:2][CH2:14][CH:12]([C:6]1[CH:5]=[C:4]([F:3])[C:9]([F:10])=[C:8]([F:11])[CH:7]=1)[OH:13]참가 물질
4
실험 절차
To a solution of methylamine (20 mL, 2.0 M in methanol, 40 mmol) was added 2-(3,4,5-trifluorophenyl)oxirane (0.17 g, 0.98 mmol) at room temperature. The reaction mixture was stirred at that temperature for 24 hours. Solvent and excessive methylamine were evaporated, leaving a solid. The solid was dissolved in dichloromethane (5 mL). To the resulting clear solution was added hexanes (15 mL), standing overnight. The solid precipitant was collected by filtration to yield the title compound (0.14 g) as a white solid.
후처리
- customSolvent and excessive methylamine were evaporated
- customleaving a solid
- waitstanding overnight
- filtrationThe solid precipitant was collected by filtration
출처 및 근거
- ORD 기록
- ord-8fbffc257eda42ab9f5c8744de2362f5
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06852731B2
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