Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 5-Chloro-3-(4-nitrophenyl)-1,2,4-thiadiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Trichloromethanethiol | HCID 6390 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-Nitrobenzamidine hydrochloride | HCID 170625 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Chloro-3-(4-nitrophenyl)-1,2,4-thiadiazole | HCID 20216376 | 40.3% |
반응 단계
A solution of 75.6 gm of sodium hydroxide in 100 ml of water was added to a stirred mixture of 101.4 gm of p-nitrobenzamidine hydrochloride, 70 gm of perchloromethyl mercaptan and 760 ml of dichloromethane, while keeping the temperature below -5° C. After additional 2 hours at -5° C., the resulting suspension was filtered, and the organic phase was separated, evaporated to dryness, and the residual solid was recrystallized from 95% ethanol, yielding 45 gm of the title compound, m.p. 143°-145° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04645841 |
| 출처 데이터셋 | uspto-grants-1987_02 |
| ORD ID | ord-8c605c6e3cf44e91b096dd9b2dbdd058 |
| 출처 메모 | uspto-grants-1987_02 |