Morpholine → HCID 57447037, 화합물

HRID 2366632노트

반응식

HRID 2366632 반응식
[CH2:1]([C:4]1[N:5]([CH2:17][CH2:18][C:19](OCC)=[O:20])[C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1)[CH2:2][CH3:3].[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[N:24]1([C:19](=[O:20])[CH2:18][CH2:17][N:5]2[C:6]3[C:15]4[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=4[N:9]=[CH:8][C:7]=3[N:16]=[C:4]2[CH2:1][CH2:2][CH3:3])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 57447034HCID 57447034, 화합물

생성물 1

HCID 57447037HCID 57447037, 화합물수율 98.4%

실험 절차

A solution of ethyl 3-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)propanoate (4.0 g, 15 mmol) in morpholine (20 mL, 0.2 mol) was heated at reflux for two days, allowed to cool to ambient temperature, and concentrated under reduced pressure to provide 5.2 g of 1-(3-morpholin-4-yl-3-oxopropyl)-2-propyl-1H-imidazo[4,5-c]quinoline.

후처리

  1. temperatureat reflux for two days
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2c0f4cd384824f02b8e2d6aa01e40e19
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697873B2

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